Cancer Stem Cells Biological Functions and Biology Diagrams Abnormal activity of the core cell-cycle machinery is seen in essentially all tumor types and represents a driving force of tumorigenesis. Recent studies revealed that cell-cycle proteins regulate a wide range of cellular functions, in addition to promoting cell division. With the clinical success of CDK4/6 inhibitors, it is becoming increasingly clear that targeting individual cell-cycle
Cell cycle regulation has an important influence on the proliferation, metastasis, and recurrence of tumor cells . In the current cancer treatment, the regulation of the cell cycle is mainly to control the expression of related genes and the activity of intracellular enzymes, proteins, or signal factors [5,6,7].
cycle machinery in cancer Biology Diagrams
A cardinal feature of cancer cells is the deregulation of cell cycle controls. Targeted drug therapy is designed to take advantage of specific genetic alterations that distinguish tumor cells from their normal counterparts. Mutated oncogenes and inactivated tumor suppressors can increase the dependency of cancer cells on G1-phase cyclin-dependent kinases, augment replication stress and DNA
Cell cycle inhibitors such as CDK and checkpoint kinase inhibitors are often used in combination with chemotherapy to target cell cycle factors for cancer treatment [21, 124, 140, 141]. In addition to CDKs, checkpoint kinases like Aurora A/B and PLKs are other targets for cancer therapy. Proteins regulating cell cycle progression are involved in the formation of most cancer types. This Review discusses the role of cell cycle proteins in cancer, the rationale for targeting them in
Targeting the cell cycle: a new approach to cancer therapy Biology Diagrams
The cell cycle represents a series of tightly integrated events that allow the cell to grow and proliferate. Critical parts of the cell cycle machinery are the cyclin-dependent kinases (CDKs), which, when activated, provide a means for the cell to move from one phase of the cell cycle to the next. Targeting the cell cycle: a new approach to
